Mast cell leukaemia
نویسندگان
چکیده
منابع مشابه
Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive
Mast cell leukemia (MCL) is a rare and aggressive disease with poor prognosis and short survival time. D816V c-KIT mutation is the most frequent molecular abnormality and plays a crucial role in the pathogenesis and development of the disease. Thus, comprehensive diagnostic investigations and molecular studies should be carefully carried out to facilitate the therapeutic choice. A MCL patient's...
متن کاملMast cell leukaemia presenting with multiple osteoporotic fractures in an elderly woman.
Osteoporotic fractures in elderly women are mainly due to postmenopausal bone loss but can sometimes be caused by a disabling haematological disease. We describe an 84-year-old woman suffering from multiple osteoporotic fractures as a manifestation of mast cell leukaemia. Mast cell leukaemia is a rare form of systemic mastocytosis with a poor prognosis and very few therapeutic options. Osteopor...
متن کاملMast Cell Leukemia with Ascites and Multiple Organs Damage
Mast Cell Leukemia (MCL), a rare subtype of systemic mastocytosis is defined by bone marrow involvement as atypical and aleukemic mast cells, if more than 20% and less than 10% of peripheral WBCs are mast cells, respectively. We met a case of aleukemic MCL presenting with anemia and ascites for 2 years, referred for BM evaluation, suspicious of leukemia. Our findings included BM involveme...
متن کاملINFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION
In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...
متن کاملMast cells and histopathologic variants of basal cell carcinoma
Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2005
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.2005.05662.x